Association of Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in breast cancer patients of Bihar: Case-control study

Breast cancer (BC) is the most frequent in women globally and main cause of cancer-related mortality. MTHFR C677T a functional polymorphism genes encoding one-carbon metabolism enzyme that affect folate may be associated with breast susceptibility. We have conducted case-control study taking 100 cases diagnosed healthy control. PCR-RFLP technique was used to detect genotype population. About 35% had normal genotype(C677C), 49% & rest 16% T677T for MTHFR. Among control frequency C677C 55% 40% 5%. were more common case as compared [χ2 (2, N = 200) 11.12, p 0.004]. T allele significantly higher (40%) (5%) (1, 400) 10.91, 0.001]. Cases 677TT risk BC than 677CC individual [OR=1.64 (1.03 2.10)] increasing T-allele significant [OR=1.07 (0.71 1.33)] (P trend 0.04). gene has strong correlation studied population can prognostic marker development cancer.